S13 Bioorganometallic Chemistry

Organizers
Associate Professor Toshiyuki Moriuchi, Osaka University, Japan
Associate Professor Hisashi Shimakoshi, Kyushu University, Japan
Professor Heinz-Bernhard Kraatz, University of Toronto Scarborough, Canada
Professor Nils Metzler Nolte, Ruhr-Universität Bochum, Germany
Professor Kenneth Kam-Wing Lo, City University of Hong Kong, China
Professor Leonard James Wright, The University of Auckland, New Zeeland


Keywords of the session

Biochemistry, Organometallic Chemistry, Medicinal Chemistry, Supramolecular Chemistry, Bioimaging


Scope of the session

Recently, the research field of bioorganometallic chemistry, which is a hybrid area between biology and organometallic chemistry, has attracted great attention and undergone rapid development. Conjugation of organometallic compounds with biomolecules such as nucleobases, amino acids, peptides, and proteins is envisioned to provide novel bioorganometallic systems depending on both functional properties. In these bioorganometallic conjugates, the organometallic group can serve as a molecular scaffold, a redox-active site, a sensitive probe, a chromophore, a biological marker, a catalytic active site, etc. A great deal of effort has been devoted to designing bioorganometallic conjugates by the introduction of organometallic compounds into biomolecules. For example, a conjugation of organometallic ferrocene scaffold as a central reverse-turn unit with dipeptide chains has been demonstrated to induce antiparallel -sheet-like, type II -turn-like, and -turn-like structures depending on the chirality and sequence of amino acids. Artificial B12 derivatives and hybrid systems have been designed to perform bio-inspired catalytic reactions. A variety of bioorganometallic compounds have been demonstrated to show biological activities. The luminescent bioorganometallic complexes have been utilized as biomolecular and cellular probes. These bioorganometallic chemistry will provide a fundamental basis for protein folding, the design of drug candidates, artificial catalysts, and biomaterials. The aim of this session is to bring together researchers from around world working in this field to present their results, form new collaborations, and discuss the future prospects of bioorganometallic chemistry.